Neurological soft signs in patients with schizophrenia: current knowledge and future perspectives in the post-genomics era

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Neurological soft signs in patients with schizophrenia: current knowledge and future perspectives in the post-genomics era

Sergi Papiol*, Mar Fatjó-Vilas and Thomas G Schulze Institute of Psychiatric Phenomics and Genomics (IPPG), Ludwig Maximilian University, Munich, Germany; Molecular and Behavioural Neurobiology, Department of Psychiatry, Ludwig Maximillian University, Munich, Germany; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Departament d...

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Neurological Soft Signs in First -Episode Schizophrenia

Neurological soft signs (NSS) refer to subtle neurological abnormalities comprising deficits in sensory integration, motor coordination, or sequencing of complex motor acts. It is generally accepted that NSS are more prevalent in schizophrenia patients, including first -episode cases, than in healthy subjects. Moreover, NSS have been consistently demonstrated in neuroleptic naïve firstepisode p...

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Potential endophenotype for schizophrenia: neurological soft signs.

INTRODUCTION Neurological soft signs (NSS) are suggested as a candidate endophenotype for schizophrenia. This article aims to review relevant literature and discuss the role of NSS in understanding schizophrenia. METHODS This is an update on a review article published in 2003. Articles from 2003 onwards were specifically reviewed and discussed with relevance to the role of NSS as endophenotyp...

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The clinical correlates of neurological soft signs in chronic schizophrenia.

Among 16 chronic schizophrenic in-patients, all had at least one neurological soft sign (NSS), and 6 (40%) had definite neurodysfunction. NSS and TD scores were highly intercorrelated, and NSS were significantly correlated with neuroleptic drug exposure. NSS correlated positively with both positive and negative symptoms and cognitive impairment but not with cerebral ventricular size on CT. Pati...

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ژورنال

عنوان ژورنال: Translational Developmental Psychiatry

سال: 2016

ISSN: 2001-7022

DOI: 10.3402/tdp.v4.30071